New mRNA Vaccines - A Huge Breakthrough
COVID Vaccine explained and the incredible medical
breakthroughs
In the past 100 years life span in the Western world has
more than doubled, from under 40 to about 80. Vaccines have been so effective
at improving health and saving and extending lives that most people in the U.S.
have no idea what it’s like to watch a child die a painful death from a tetanus
infection or to witness a loved one experience brutal paralysis and death from
polio. Providing and supporting vaccinations is a key tool in today’s public
health toolbox.
There are very few effective antiviral medicines (as opposed
to anti-bacterial medications, that is antibiotics). The vast majority of viral
infections can only be treated by prevention with vaccinations.
There is a lot of conflicting information about the current
COVID vaccine. Unfortunately most of this is spread through social media and
word of mouth, without appropriate review or scientific background.
Many are hesitant; mostly due to this misinformation. The
new mRNA technology is a game changer both in efficacy, but more importantly in
safety.
To really understand what is going on, it is necessary to
explain how viruses work, how the body defends itself, and how vaccines work.
1. Natural
Defenses
The way one’s body defends itself against foreign invaders,
such as bacteria and viruses is truly incredible. We are constantly exposed to
all types of bacteria and viruses. The body has two major defense systems;
antibodies and killer T-cells.
The antibody system is truly amazing. When a foreign invader
comes into our body, there are special defenders that recognize it as foreign,
and start the process of developing antibodies specific to that invader. This
takes about a week or two; and during that time the virus or bacteria can wreak
its havoc. The fascinationg thing is that we have the ability to make millions
or billions of different antibodies, specific to each invader. How this happens
is not well understood.
The antibodies attach to the invader (in the case of COVID
we produce antibodies to the so-called spike protein). Once attached, the
antibody protein changes its shape and attracts a white blood cell, a special
army of cells that “eat” invaders and debris, and so destroys the virus. (The
actual process is that the cell surrounds the marked virus, places it in a
vacuole and applies enzymes that digest it).
Aside from our incredible ability to make antibodies against
virtually anything, the system also has the ability NOT to make antibodies
against our own body. This is because each of our cells have special markers
that tell our defenders that these belong there. Occasionally this fails, and
we do make auto-antibodies, such as in diseases like Rheumatoid arthritis and
lupus.
The killer T-cell system is similar to the antibody system,
in that our body has the ability to make special killer cells that specifically
recognize the invader. Again this takes 1-2 weeks.
Once we have fought off the invader, by either system, our
body remembers by keeping a few cells that specialize in that specific
antibody; if the invader comes back it can ramp up antibodies in 24 hours or
less.
2. How
our body functions
It is important in this context to understand how our body
works, specifically how it makes proteins. Our genetic code is DNA. This can be
thought of as a complete set of building plans used to operate. In a
construction sense, this would contain all different plans, such as plumbing,
electric, etc.
If our cell wants to make something, it produces a copy of
that specific blueprint. We call this messenger RNA or mRNA. It sends the mRNA
to the factory, also known as the ribosome. The factory then makes the protein.
For example, to make insulin, the cell makes an insulin mRNA, sends it to the
ribosomes, and insulin is released.
Most mRNA is destroyed after one use, some can be reused,
but these blueprints usually only last a few minutes, or in some cases up to a
week or two. It is quite unstable.
This process is simple, the complicated part is the
co-ordination of when certain proteins need to be made and released, or
production needs to stop. However this is not important in a viral infection.
3. How
a Virus works
The COVID virus is quite simple. It is a big piece of mRNA
surrounded by a capsule. It injects the mRNA into the cell, and the mRNA makes
its way to the factory (ribosomes). Then it makes ALL the parts needed to make
a virus, including copies of the mRNA, and the coating. The viral mRNA can
survive from several hours to a day; enough time to make several thousand virus
particles. However this process is quite error prone, and it seems that only
about 10-100 of these new viral products are actually functional. The rest are
so full of errors they don’t work.
After about 10,000 virus particles are made, the cell bursts
and release the infectious virus, and the process continues. This only takes a
few hours, so within 24 hours your body has made hundreds of thousands or
millions of infectious viral particles from the approximately 1000 initial
virus particles you inhaled.
4. Vaccines
Currently, because viruses use our own bodies “factories” to
make new viruses, they have little or no unique metabolic processes. Bacteria,
like strep, are physiologically different and reproduce on their own, and have
different enough metabolic processes that we can produce antibiotics that are
safe for us but can kill them.
The development of vaccines was a huge advance, and mRNA
vaccines are a game changer. The theory of vaccination is to induce our body to
create the antibodies needed to kill the virus. Then the body will have a
memory, and can defend against COVID within 24 hours, not 1-2 weeks.
The first vaccines were live viruses that were mutated, intentionally
or not, to be less infectious. The first was cowpox, a live virus which made us
produce antibodies against smallpox. The early polio vaccines were live
viruses, and could rarely actually cause paralysis. Current polio vaccines are
not live viruses.
Until mRNA vaccines, the vaccinations contained specific
protein parts, or dead virus, usually attached to an adjuvant, like aluminum,
to help induce an immune response. Development of the appropriate combination
of protein and adjuvant could take years; and often the first tries were
unsuccessful.
5. mRNA
Technology and vaccines
As noted, the mRNA is very unstable and quickly destroyed.
Over the past 25 years, researchers had been searching for ways to stabilize
the mRNA and then have methods to deliver it to the cellular factories without
it being destroyed. The thought was that we could treat diseases where people
are missing specific proteins and use the mRNA to have the body make it.
Vaccines were the other possibility.
So how does the current mRNA vaccine work? Researchers
quickly were able to map the entire COVID virus RNA “blueprint”. Then they
looked at patients who had recovered from COVID and found they all had
antibodies against a part of the virus called the “spike protein”. Quickly they
determined which part of the mRNA made (or coded for) the spike protein and
were able to put it in a special capsule to deliver it to our cellular
factories to make the spike protein, and only the spike protein. Within 2
months of the pandemic starting they had this perfected.
Compared to previous vaccines (which are generally safe)
these vaccines are incredibly safe and reliable. First, there are no adjuvants,
no live or killed virus, and no extra substances. The protein produced is the
spike protein – the same exact one that your body would be full of if you got
the infection. The antibodies produced are the exact same ones you would make
if you got infected.
The mRNA lasts less than two weeks, and is localized in the
muscle where it is injected.
You might hear about side effects, such as blood clots and
myocarditis. In actuality these are likely related to the antibodies, and they
occur far more frequently with actual infection. The incidence of serious side
effects is less than one in a million, less than most current vaccines for
other diseases, and less than most common oral medications (including
Tylenol!).
The COVID virus has the ability to infect and damage your
lungs, nasal passages, kidneys, heart and brain and many other tissues. About
60% of recovered have some long term effects, often very subtle.
All the vaccines in current use were based on the original version
of COVID. As the virus has mutated, the current vaccines are less effective,
but still highly protective against serious disease. It appears that higher
antibody levels protect better against the newer mutations.
The levels of antibodies do drop slightly after about 6
months. We do not know if this will affect risk to infection, but since the vaccine
is so safe it may be worthwhile getting a booster. Similarly, if you had COVID
infection, scientists have found that antibody levels are much lower than after
the vaccine, so it is a good idea to get at least one vaccination. As long as
the infection is cleared up the shot will be effective – and can be given as
early as 10 days to 2 weeks after infection. The vaccine has also been shown to
decrease symptoms in long haulers.
Some groups have latched on the fact that the vaccines have
not obtained full FDA approval. To get full approval, FDA investigators need to
personally inspect all manufacturing facilities in extreme detail (which they
have started for emergency approval), as well as do complete reviews of all
data. This is a procedure that is organized to take a minimum of 6-10 months so
any side effects and changes in doses can be carefully evaluated. The process
also is there to ensure future production maintains the protocols and safety
measures that are being used. There are numerous cancer drugs that have similar
emergency approval.
mRNA technology is a game changer in safety and efficacy. It uses a copy of real viral mRNA and makes us produce the exact same antibodies as if we were infected. The risks of infection
are so much higher this should be a no-brainer.