Colon Cancer and Aspirin

In the past, aspirin and NSAID (motrin, aleve, etc) use has been shown to decrease the risk of colon cancer by 20-40%. Although the mechanism is obscure, some believe it is related to the prostaglandin receptors in the colon.

Few of us take full dose aspirin or NSAIDs on a daily basis, and there had been no studies using 81mg or baby aspirin which is much more commonly taken.

Now, in a new report researchers showed that continuous use of low-dose aspirin (75–100 mg per tablet) for ≥5 years was associated with a 27% reduction in colorectal cancer risk. Long-term use of nonaspirin NSAIDs (≥2 prescriptions annually for ≥5 years) was associated with a 36% reduction in risk. There was no clear benefit from irregular use.

Unless you have a bleeding disorder, or a contraindication such as an ulcer, taking a baby aspirin a day, starting at about age 40, may be beneficial. You should discuss this with your physician to be sure this is OK for you.

Douglas K. Rex, MD Reviewing Friis S et al., Ann Intern Med 2015 Sep 1; 163:347